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|Title: ||Design Synthesis and Functionalization of Self assembled Supramolecular Coordination Complexes|
|Researcher: ||Rekhamoni Das|
|Guide(s): ||Rajesh Chakrabarty|
|Registration Date: ||09/03/2016|
|Abstract: ||With the elucidation of coordination behaviour of transition metals by Alfred Werner in 1893, the field of coordination chemistry have grown tremendously. In recent decades two branches of coordination chemistry have emerged, one is Metal Organic Framework (MOFs) which consist of infinite networks or inorganic clusters bridged by simple organic linkers through metal-ligand coordination bonds and the other is supramolecular coordination complexes which consist of discrete systems in which carefully selected metal centres undergo self assembly with ligands containing multiple binding sites oriented with speciand#64257;c angularity to generate a and#64257;nite supramolecular complex. Supramolecular coordinaton complex refers to the domain of chemistry beyond that of molecules and focuses on the chemical systems made up of a discrete number of assembled molecular subunits or components .The forces responsible for the spatial organization of supramolecules may vary from weak (intermolecular forces, electrostatic forces or hydrogen bonding) to strong covalent bonding. It has led to the synthesis of materials exhibiting unusual sensing, magnetic, optical, catalytic, drug delivery properties and for researchers investigating the structure and function of biomolecules .The assembly of supramolecular ensembles have given rise to various 2D and 3D molecular architectures of different shapes and sizes. The functionalisation of supramolecular complexes has also been extensively investigated over the past few years with an aim to develop nanoscale ensembles that can and#64257;nd applications in diverse and#64257;elds such biological systems, host-guest chemistry, cavity-directed synthesis, catalysis, photonics, redox activity, magnetic behaviour, self-organization, and sensing. However, almost all the coordination nanocages reported so far are hydrophobic, which greatly limits their applications in aqueous condition. If we turn these nanocages into colloids through surface functionalization with hydrophilic polymers and moreover if this supramolecular nanocages are designed in such a way that have pendant groups, it might be pave a facile way to incorporate a wide range of chemical functionalities on appropriate assemblies with further prospect of post-synthetic modification. Considering the recent developments the current focus of our research work will be to design definite supramolecular coordination complexes by using directional bonding approach and subsequently modify the complexes for surface functionalization to incorporate moieties that are amenable to further modification. To achieve the goal we intend to design ligands with binding sites and directionality having pendent moieties, which are amenable to further transformation. These tectons would then be used to construct supramolecular ensembles using metal nodes such as Zn, Cd, Co, Pt, Pd etc. The resulting ensembles would then be functionalized via various well-known condensation reactions such as Huisgen type AAC reactions, amidation etc. with a variety of functional groups to give functionalized supramolecules under mild conditions. These functional ensembles would be tested for their potential applications as molecular sensor, drug-delivery cages etc.
|Appears in Department:||Department of Chemistry|
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